The irony is that AFAIK the ME cleaner itself depends on exploiting some vulnerability in ME in order to disable it... so it may get more difficult in the long term.
The good news on that front is most board manufacturers abandon updates after a year or two. My ASUS mobo right now was released in 2013 and saw its last firmware update in late 2014. With the exception of the most modern boards, you can generally assume there will be no more updates for your hardware after a year or so.
