Hmm... Should we follow his idea how to reach his goals, or maybe we should follow his goals with our best? Nobel idea how to invest his money is based on the understanding science as it was at XIX century. But now science is different and is changing further constantly. So if we follow Nobel last will, than Nobel Prize would become irrelevant, having zero influence on science, just some tradition from the past to give money for good managers or for respectable elderly scientists choosed from hundreds of other equally respectable and elderly scientists by some qualities having nothing to productivity in science or revolutionary ideas. Alternatively we can try to adapt the Nobel Prize to new reality, allowing it to reflect current state of affairs and to hold its influence on science.

I'm not a lawer, so I don't know is it possible to change Nobel Prize principles. All I want is to point to futility of blind following the old rule.